Physiological properties | Effect of D-serine on NMDARs | ||||||
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Cell type | Resting Vm | Rin | τ | Spike amplitude | Spike duration at half-amplitude | Electrical stimuli | Pressure application of NMDA |
(mV) | (Mω) | (ms) | (mV) | (ms) | (% increase) | (% increase) | |
Pyramidal cells | −76.25 ± 0.62 n = 39 | 99.26 ± 1.88 n = 39 | 25.49 ± 1.78 n = 39 | 99.26 ± 1.88 n = 39 | 1.17 ± 0.05 n = 39 | 51.66 ± 7.89 n = 17 | 49.20 ± 8.29 n = 10 |
Interneurons | −62.11 ± 1.54 n = 19 | 346.85 ± 21.63 n = 19 | 63.03 ± 5.0 n = 19 | 80.24 ± 1.89 n = 19 | 1.38 ± 0.10 n = 19 | 25.07 ± 5.65 n = 12 | 28.15 ± 3.84 n = 10 |
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Values are means ± s.e.m. Electrical stimuli: electrically evoked NMDAR currents in a low-Mg2+ ACSF (0.1 idm) in the presence of NBQX (20 μm), picrotoxin (50 μm), CGP 52432 (10 μm) and strychnine (0.5 μm). Pressure application of NMDA: responses to local pressure application of NMDA (100 μm) in the presence of TTX (0.5 μm).